Kimia Medisinal 3


Metabolisme obat adalah proses pengubahan senyawa yang relatif non polar, menjadisenyawa yang lebih polar sehingga mudah dikeluarkan dari tubuh. Banyak molekul senyawaorganik mudah larut dalam lemak dan diserap oleh saluran cerna dan masuk ke peredarandarah. Molekul tersebut kemudian menembus membran biologis secara difusi pasif,mencapai organ sasaran dan menimbulkan efek farmakologis.

Reaksi konjugasi obat atau senyawa organik asing dengan asam glukuronat, sulfat,glisin, glutamin dan glutation dapat mengubah senyawa induk atau hasil metabolit fasa Imenjadi metabolit yang leboh polar, mudah larut dalam air, bersifat tidak toksik dan tidakaktif dan kemudian di ekskresikan melalui ginjal atau empedu.

Link video youtube : https://youtu.be/w9MW-4iMigM

Comments

  1. Mery Sunardea 28 February 2023 at 19:43

    This comment has been removed by the author.

    ReplyDelete
  2. Mery Sunardea 28 February 2023 at 19:44

    Berdasarkan dengan asam glukuronat dan sulfat, pada proses konjungsi ini asam amino tidak diubah menjadi koenzim aktif, mengapa demikian?

    ReplyDelete
  3. Mery Sunardea 28 February 2023 at 20:03

    Pada video disebutkan jika konjugasi glisin terdapat proses dua langkah. Jelaskan bagaimana proses dua langkah konjugasi glisin tersebut?

    ReplyDelete
  4. Mery Sunardea 28 February 2023 at 20:04

    Apa saja faktor yang mempengaruhi konjugasi asam amino tersebut?

    ReplyDelete

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